GMP Protein in Vitro Modification Service

Protein modification mainly refers to the process of chemically modifying proteins in vitro to change the properties of the protein, such as stability, solubility, and half-life, making it more suitable for therapeutic or diagnostic applications. With the development of technology, in vitro modification of proteins in GMP-grade laboratories allows for strict control of experimental conditions and procedures, ensuring higher safety and efficacy of the final product. Currently, GMP protein in vitro modification has become one of the very crucial technologies in the field of medicine and biotechnology, which makes significant contributions to human health by helping researchers prepare high-quality, safe, and effective protein drugs.

Creative BioMart is a professional biotechnology company dedicated to providing high-quality GMP protein in vitro modification services to customers worldwide. With a team of senior scientists and technical professionals, rich experience in protein modification, and advanced laboratory equipment, we are able to provide customers with one-stop service from program design to product delivery.

Technical Focus of Our Service

Compliance with GMP regulations and strict quality control throughout the service.

• GMP Protein Chemical Modification

• GMP Protein Phosphorylation Modification

By introducing phosphate groups into GMP protein molecules, the electronegativity and hydrophilicity of proteins can be increased, thus improving their activity and stability. This modification is mainly applied to growth factor and cytokine protein drugs.

• GMP Protein Glycosylation Modification

Attaching a sugar chain to a GMP protein can increase the molecular weight of the protein, change its immunogenicity, and improve its stability in the body. This modification method is mainly applied to insulin and interferon.

• GMP Protein Hydroxylation Modification

Introducing hydroxyl groups into GMP protein molecules can change the polarity and hydrophilicity of proteins, thus improving their stability in vivo. This technique has become prevalent in enzyme preparations and vaccines.

• GMP Protein Methylation Modification

Transferring methyl groups to GMP protein molecules can change the conformation and activity of proteins. It is usually of value in the production of some hormones and neurotransmitter drugs.

• GMP Protein Acetylation Modification

Attaching an acetyl group to GMP protein molecule can change the conformation and activity of the protein. This technique is critical for the development of enzyme and antibody drugs.

Figure 1. Types of in vitro chemical modification of GMP proteins.

• GMP Protein Genetic Modification

Genetic engineering techniques are commonly used to modify GMP proteins. For example, the gene editing technique (CRISPR-Cas9 system) can knock out, knock-in or mutate a target gene, thereby altering the activity, structure, and function of the protein.

• GMP Protein Chemical Modification

To stimulate an immune response in the body by altering the immunogenicity of GMP proteins so that they become immunogens or antigens. This process usually involves chemical or genetic modification of GMP proteins.

Reasons to Choose Us

• Experienced. With many years of experience in GMP protein modification and familiarity with various protein structures and modification methods, we can provide personalized modification solutions to meet different drug development needs according to customer demands.
• Strict quality control system. Our laboratory boasts a stringent quality control system to ensure all experimental procedures adhere to GMP requirements.
• Advanced equipment. We offer a range of GMP-related equipment for the separation and purification of proteins, as well as for chemical modification and genetic engineering to increase experiment accuracy and reproducibility.
• Customized service. We provide a series of professional and personalized customization services, including customized GMP protein modification protocols and reaction conditions.

Creative BioMart, a reputable company in the biotechnology industry, specializes in offering GMP protein services. Our extensive experience, professional technical team, and advanced laboratory equipment provide us with a distinct advantage in the field of GMP protein modification. Please do not hesitate to contact us if you are interested in our services.