Cardiovascular Disease

Cardiovascular disease (CVD) is a circulatory disease caused by abnormalities of the heart and vascular conditions, which has now become a major problem worldwide threatening human health due to its high prevalence. Ischemic myocardial infarction, heart failure, atherosclerosis, and many other CVDs are caused by high oxidative stress in the microenvironment, which leads to severe impairment of cardiac function. In recent years, stem cell therapy has become a new direction in current CVD research. Mesenchymal stem cells (MSCs) are directly induced to differentiate into endothelial cells through inducers such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), ascorbic acid, and heparin, which promotes new blood vessel formation.

Figure 1. Schematic representation of cardiomyocytes (CM) as source and target of vascular endothelial growth factor-A (VEGF-A). (Braile M, et al., 2020)

CVD & Growth Factors

• Vascular Endothelial Growth Factor (VEGF)

VEGF is involved in vasculogenesis and development as the most potent angiogenic factor and ubiquitous target for multiple diseases of CVD. Abnormal expression of VEGFA and its receptor has been shown to cause vascular diseases such as hemangiomas and arteriovenous malformations, cardiac diseases, and abnormal placental function.

• Fibroblast Growth Factors (FGFs)

FGFs are potent regulators of cell proliferation differentiation and function, which play an important role in the normal development of stem cells in the body, tissue maintenance, trauma repair, and angiogenesis. Current studies have shown that FGF18 can cardiomyocytes to improve oxidative stress, providing new research ideas and targets for the treatment of pathological cardiac hypertrophy.

• Coagulation Factors

Coagulation factors are substances in plasma and tissues that are directly involved in blood clotting, most of which are synthesized by the liver. Among them, the deficiency of coagulation factor VIII (FVIII) is a key factor in the development of hemophilia, in which patients suffer from lifelong abnormalities in coagulation and are prone to bleeding.

• Platelet-Derived Growth Factors (PDGFs)

PDGFs are serum growth factors that are synthesized by megakaryocytes and stored in platelets. He acts as a potent mitogenic and chemotactic protein and plays a role in the processes of angiogenesis and vascular growth, which are necessary for early development and wound healing. Numerous studies have identified PDGF-B as a mediator of the interactions between vascular endothelial cells, platelets, and monocyte giant cells during the formation of atherosclerosis (AS), which is important in the development of vascular diseases.

We Provide Multiple Products but not Limited to

• Recombinant Human FGF2 protein, GMP Grade
• Recombinant Human FGF18 Protein, GMP Grade
• Recombinant Human VEGFA protein, His-tag, GMP Grade
• Recombinant Human VEGFR Protein, Fc-tag, GMP Grade
• Recombinant Human PDGFA protein, Fc-tag, GMP Grade
• Recombinant Human PDGFB protein, GMP Grade
• Recombinant Human F13A1 Protein, GMP Grade

Reasons to Choose Us

• High-quality products. A wide variety of high purity and high activity GMP growth factors are available for you to choose from, and personalized customization services are available to meet special needs.
• GMP-grade equipment. Our laboratory has a strict quality control system to ensure that all production processes and products meet GMP requirements.
• One-stop platform. Cover a series of services from formulation, and standardized production to delivery, with quick feedback on customers' products.

Creative BioMart offers high-quality GMP growth factors and related customized services for advancing research in cardiovascular disease and hematology. If you are interested in our services, please contact us.