Tumor Immunity

Tumor presents a significant threat to human health, and its treatment primarily relies on surgery, radiotherapy, and chemotherapy. Immunotherapy stands as an innovative technology that has garnered substantial attention in cancer treatment research. In the tumor microenvironment (TME), certain cytokines contribute to the host's anti-tumor response as key mediators of cellular communication. Meanwhile, cytokines and their receptors may serve as significant tumor targets in clinical cancer therapy. Currently, the growing research on cytokine family, tumor immunity, and cancer development allows for the utilization of GMP-grade cytokines as an efficacious tool to bolster clinical cancer-targeted therapy and advance the field of biomedicine.

Creative BioMart can provide a series of high-quality GMP cytokines and customized services and is dedicated to the research of tumor immunity.

Figure 1. Role of major cytokines in the tumor microenvironment. (Seruga B, et al., 2008)

Applications of Cytokines

• Interleukin

Interleukins (ILs) are a group of synthetic cytokines that impact a broad range of cells. Specifically, interleukin-2 (IL-2) was the first cytokine utilized as an adjuvant in tumor therapy. Research indicates that IL-2 stimulates natural killer (NK) cells and T cells, which promotes and enhances cytotoxic activity. Moreover, the ability of IL-2 to expand T cells without affecting their activity reinforces its use as an immunotherapeutic agent for cancer patients.

• Interferon

Interferons (IFNs) are pleiotropic cytokines displaying antiviral, antitumor, and immunomodulatory properties that play a crucial role in coordinating immune responses. IFN-α, in particular, is synthesized by diverse cell types and exhibits multifaceted actions, including anti-angiogenesis, facilitation of dendritic cell (DC) migration, and inhibition of cancerous cells, rendering it a pivotal agent in the treatment of cancer.

• Tumor Necrosis Factor (TNF)

As the earliest and most representative drug in tumor immunotherapy, TNF is mainly produced by activated macrophages, NK cells, and T lymphocytes. Numerous basic studies have shown that TNF can increase the concentration of chemotherapeutic drugs in tumors by 4-6 times, thus producing significant anti-tumor effects. In addition, TNF can be used in combination with drugs such as doxorubicin to enhance the cytotoxic effect on drug-resistant cells.

We Provide Multiple Products but not Limited to

• Recombinant Human IL-2 Protein, GMP Grade
• Recombinant Human IL11 protein, His-tag, GMP Grade
• Recombinant Human Interferon Alfa 2a Protein, GMP Grade
• Recombinant Human Interferon beta-1b Protein, GMP Grade
• Recombinant Human TNF protein, GMP Grade
• Recombinant Rat Tnf protein, His-tag, GMP Grade

Advantages of Our Products

• High Safety

The production process follows GMP standards and a strict quality control system to ensure that the product is free from bacterial toxins, mycoplasma, and virus contamination.

• High Purity

After liquid chromatography, ion exchange chromatography, mass spectrometry, and other biotechnology to remove endotoxins and impurities, the product purity can reach >95%.

• High Efficiency

The production process largely preserves the biological function of the product, ensuring high biological activity and stability.

Reasons to Choose Us

• GMP-grade. Our laboratory has a strict quality control system to ensure that all production processes meet GMP requirements.
• Multiple products. Various types of high-quality GMP cytokines are available for you to choose from, while professional and personalized customized service can meet your special needs.
• Fast delivery. Timely processing of orders, in a short time to ensure that customers receive the products.

Creative BioMart can provide a comprehensive selection of GMP cytokines and associated services to advance drug discovery and biomedical research. If you are interested in our services, please contact us.