Native Human F2 Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
F2-106THP |
| Common Name: |
F2 |
| Product Name: |
Native Human F2 Protein, GMP Grade |
| Product Overview: |
Native Human F2 Protein was purified from Human Plasma and was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. |
| Source: |
Human Plasma |
| Species: |
Human |
| Molecular Mass: |
Not Available |
| AA Sequence: |
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE |
| Endotoxin: |
<0.001 EU/μg by the LAL method |
| Applications: |
The product is indicated as an aid to hemostasis whenever oozing blood and minor bleeding from capillaries and small venules are accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical. |
| Usage: |
Oozing blood and minor bleeding |
| Gene Name: |
F2 coagulation factor II (thrombin) [ Homo sapiens (human) ] |
| Official Symbol: |
F2 |
| Synonyms: |
F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1; |
| GeneID: |
2147 |
| mRNA Refseq: |
NM_000506 |
| Protein Refseq: |
NP_000497 |
| MIM: |
176930 |
| UniProt ID: |
P00734 |
Not For Human Consumption!
