Native Human F9 Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
F9-095THP |
| Common Name: |
F9 |
| Product Name: |
Native Human F9 Protein, GMP Grade |
| Product Overview: |
Native Human F9 Protein was purified from Human Plasma and was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. |
| Source: |
Human Plasma |
| Species: |
Human |
| Bio-activity: |
500 U/10ml |
| Molecular Mass: |
Not Available |
| AA Sequence: |
Not Available |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Applications: |
The product is indicated for the prevention and control of hemorrhagic episodes in hemophilia B patients. It is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding or who require rapid reversal of therapy. |
| Usage: |
Hemorrhagic episodes in hemophilia B |
| Gene Name: |
F9 coagulation factor IX [ Homo sapiens (human) ] |
| Official Symbol: |
F9 |
| Synonyms: |
F9; coagulation factor IX; Christmas disease; Factor IX; FIX; hemophilia B; plasma thromboplastic component; F9 p22; FIX F9; factor 9; factor IX F9; serine protease; Christmas factor; plasma thromboplastin component; P19; PTC; HEMB; THPH8; MGC129641; MGC129642; |
| GeneID: |
2158 |
| mRNA Refseq: |
NM_000133 |
| Protein Refseq: |
NP_000124 |
| MIM: |
300746 |
| UniProt ID: |
P00740 |
Not For Human Consumption!
