Recombinant Human BMP2 Protein without tag was expressed in CHO and was produced in an animal component free process under cGMP guidelines.
Description:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
Source:
CHO
Species:
Human
Bio-activity:
1.5 mg/mL
Molecular Mass:
Not Available
AA Sequence:
Not Available
Endotoxin:
<0.001 EU/μg of the peptide by the LAL method
Purity:
> 99 % by SDS-PAGE and HPLC analysis
Applications:
indicated for the treatment of acute tibia fractures in adults, as an adjunct to standard care using open fracture reduction and intramedullary unreamed nail fixation.indicated for single-level lumbar interbody spine fusion as a substitute for autogenous bone graft in adults with degenerative disc disease who have had at least 6 months of non-operative treatment for this condition.
Not For Human Consumption!
