Recombinant Human BMP2 Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
BMP2-114THP |
| Common Name: |
BMP2 |
| Product Name: |
Recombinant Human BMP2 Protein, GMP Grade |
| Product Overview: |
Recombinant Human BMP2 Protein without tag was expressed in CHO and was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. |
| Source: |
CHO |
| Species: |
Human |
| Bio-activity: |
1.5 mg/mL |
| Molecular Mass: |
Not Available |
| AA Sequence: |
Not Available |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Purity: |
> 99 % by SDS-PAGE and HPLC analysis |
| Applications: |
indicated for the treatment of acute tibia fractures in adults, as an adjunct to standard care using open fracture reduction and intramedullary unreamed nail fixation.indicated for single-level lumbar interbody spine fusion as a substitute for autogenous bone graft in adults with degenerative disc disease who have had at least 6 months of non-operative treatment for this condition. |
| Usage: |
Acute tibia fractures |
| Gene Name: |
BMP2 bone morphogenetic protein 2 [ Homo sapiens (human) ] |
| Official Symbol: |
BMP2 |
| Synonyms: |
BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; bone morphogenetic protein 2A; BDA2; |
| GeneID: |
650 |
| mRNA Refseq: |
NM_001200 |
| Protein Refseq: |
NP_001191 |
| MIM: |
112261 |
| UniProt ID: |
P12643 |
Not For Human Consumption!
