Recombinant Human CR1 Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
CR1-111THP |
| Common Name: |
CR1 |
| Product Name: |
Recombinant Human CR1 Protein, GMP Grade |
| Product Overview: |
Recombinant Human CR1 Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. |
| Species: |
Human |
| Molecular Mass: |
Not Available |
| AA Sequence: |
Not Available |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Applications: |
Investigated for use/treatment in transplant (rejection), kidney disease, and rheumatoid arthritis. |
| Usage: |
Transplant (rejection), kidney disease, and rheumatoid arthritis |
| Gene Name: |
CR1 complement component (3b/4b) receptor 1 (Knops blood group) [ Homo sapiens (human) ] |
| Official Symbol: |
CR1 |
| Synonyms: |
CR1; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1, including Knops blood group system; complement receptor type 1; CD35; KN; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component receptor 1; C3BR; C4BR; |
| GeneID: |
1378 |
| mRNA Refseq: |
NM_000573 |
| Protein Refseq: |
NP_000564 |
| MIM: |
120620 |
| UniProt ID: |
P17927 |
Not For Human Consumption!
