Recombinant Human DNASE1 Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
DNASE1-109THP |
| Common Name: |
DNASE1 |
| Product Name: |
Recombinant Human DNASE1 Protein, GMP Grade |
| Product Overview: |
Recombinant Human DNASE1 Protein without tag was expressed in CHO and was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
| Source: |
CHO |
| Species: |
Human |
| Bio-activity: |
1 mg/mL |
| Molecular Mass: |
29253.9 Da |
| AA Sequence: |
LKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Purity: |
> 99 % by SDS-PAGE and HPLC analysis |
| Applications: |
Used as adjunct therapy in the treatment of cystic fibrosis. |
| Usage: |
Cystic fibrosis (CF) |
| Gene Name: |
DNASE1 deoxyribonuclease I [ Homo sapiens (human) ] |
| Official Symbol: |
DNASE1 |
| Synonyms: |
DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; DNase I, lysosomal; human urine deoxyribonuclease I; DRNI; FLJ38093; FLJ44902; DKFZp686H0155; |
| GeneID: |
1773 |
| mRNA Refseq: |
NM_005223 |
| Protein Refseq: |
NP_005214 |
| MIM: |
125505 |
| UniProt ID: |
P24855 |
Not For Human Consumption!
