Recombinant Human F8 Protein, Fc-tag, GMP Grade


Cat# Product Name Availability Size Price Qty
F8-102THP Recombinant Human F8 Protein, Fc-tag, GMP Grade 10ug $998.00
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Cat#:  F8-102THP
Common Name:  F8
Product Name:  Recombinant Human F8 Protein, Fc-tag, GMP Grade
Product Overview:  Recombinant Human F8 Protein fused with a Fc tag and was produced in an animal component free process under cGMP guidelines.
Description:  This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Species:  Human
Tag :  Fc
Bio-activity:  1500 U/3ml
Molecular Mass:  220000.0 Da (Apparent, B-domain deleted)
AA Sequence:  Not Available
Endotoxin:  <0.001 EU/μg of the peptide by the LAL method
Purity:  > 99 % by SDS-PAGE and HPLC analysis
Applications:  Indicated for the treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).
Usage:  Haemophilia A (congenital factor VIII deficiency)
Gene Name:  F8 coagulation factor VIII, procoagulant component [ Homo sapiens (human) ]
Official Symbol:  F8
Synonyms:  F8; coagulation factor VIII, procoagulant component; F8C; coagulation factor VIII; DXS1253E; Factor VIIIF8B; FVIII; HEMA; hemophilia A; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc; AHF; F8B;
GeneID:  2157
mRNA Refseq:  NM_000132
Protein Refseq:  NP_000123
MIM:  300841
UniProt ID:  P00451
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