Recombinant Human F9 Protein, GMP Grade


Cat# Product Name Availability Size Price Qty
F9-094THP Recombinant Human F9 Protein, GMP Grade 10ug $998.00
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Cat#:  F9-094THP
Common Name:  F9
Product Name:  Recombinant Human F9 Protein, GMP Grade
Product Overview:  Recombinant human F9 Protein without tag was produced in an animal component free process under cGMP guidelines.
Description:  This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Species:  Human
Molecular Mass:  Not Available
AA Sequence:  Not Available
Endotoxin:  <0.001 EU/μg of the peptide by the LAL method
Purity:  > 99 % by SDS-PAGE and HPLC analysis
Applications:  The product is indicated for the use in adults and children with hemophilia B for control and prevention of bleeding episodes, routine prophylaxis and perioperative management. In the EMA approval, it is also indicated for on-demand treatment of bleeding episodes. Hemophilia B is characterized by a deficiency in the coagulation factor IX which results in prolonged oozing after injuries and delayed or recurring bleeding prior wound healing. Hemophilia B patients present more frequent bleeding episodes during childhood and adolescence than in adulthood.
Usage:  Hemophilia B
Gene Name:  f9 coagulation factor 9 [ Xenopus (Silurana) tropicalis ]
Official Symbol:  F9
Synonyms:  F9; coagulation factor 9; gla domain; coagulation factor IX; coagulation factor 9 (plasma thromboplastic component, Christmas disease, hemophilia B); fix; ptc; hemb;
GeneID:  496659
mRNA Refseq:  NM_001011223
Protein Refseq:  NP_001011223
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