Recombinant Human FGF18 Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
FGF18-068THP |
| Common Name: |
FGF18 |
| Product Name: |
Recombinant Human FGF18 Protein, GMP Grade |
| Product Overview: |
Recombinant Human FGF18 Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. |
| Species: |
Human |
| Endotoxin: |
<0.1 EU/μg of the protein by the LAL method |
| Purity: |
> 99 % by SDS-PAGE and HPLC analysis |
| Applications: |
Sprifermin has been used in trials studying the treatment of Osteoarthritis, Knee and Cartilage Injury of Knee. |
| Usage: |
Osteoarthritis of the Knee; Cartilage Injury of Knee; Isolated Cartilage Injury of the Knee |
| Gene Name: |
FGF18 fibroblast growth factor 18 [ Homo sapiens (human) ] |
| Official Symbol: |
FGF18 |
| Synonyms: |
FGF18; fibroblast growth factor 18; FGF 18; ZFGF5; FGF-18; |
| GeneID: |
8817 |
| mRNA Refseq: |
NM_003862 |
| Protein Refseq: |
NP_003853 |
| MIM: |
603726 |
| UniProt ID: |
O76093 |
Not For Human Consumption!
