Recombinant Human GAD1 Protein, GMP Grade


Cat# Product Name Availability Size Price Qty
GAD1-089THP Recombinant Human GAD1 Protein, GMP Grade 10ug $998.00
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Cat#:  GAD1-089THP
Common Name:  GAD1
Product Name:  Recombinant Human GAD1 Protein, GMP Grade
Product Overview:  Recombinant Human GAD1 Protein without tag was produced in an animal component free process under cGMP guidelines.
Description:  This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Species:  Human
Molecular Mass:  Not Available
AA Sequence:  Not Available
Endotoxin:  <0.001 EU/μg of the peptide by the LAL method
Purity:  > 99 % by SDS-PAGE and HPLC analysis
Applications:  Investigated for use/treatment in diabetes mellitus type 1.
Usage:  Diabetes mellitus type 1
Gene Name:  GAD1 glutamate decarboxylase 1 (brain, 67kDa) [ Homo sapiens (human) ]
Official Symbol:  GAD1
Synonyms:  GAD1; glutamate decarboxylase 1 (brain, 67kDa); GAD, glutamate decarboxylase 1 (brain, 67kD); glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform; GAD; SCP; CPSQ1; FLJ45882;
GeneID:  2571
mRNA Refseq:  NM_000817
Protein Refseq:  NP_000808
MIM:  605363
UniProt ID:  Q99259
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