Cat# | Product Name | Availability | Size | Price | Qty |
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GAD1-089THP | Recombinant Human GAD1 Protein, GMP Grade | 10ug | $998.00 |
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Cat#: | GAD1-089THP |
Common Name: | GAD1 |
Product Name: | Recombinant Human GAD1 Protein, GMP Grade |
Product Overview: | Recombinant Human GAD1 Protein without tag was produced in an animal component free process under cGMP guidelines. |
Description: | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. |
Species: | Human |
Molecular Mass: | Not Available |
AA Sequence: | Not Available |
Endotoxin: | <0.001 EU/μg of the peptide by the LAL method |
Purity: | > 99 % by SDS-PAGE and HPLC analysis |
Applications: | Investigated for use/treatment in diabetes mellitus type 1. |
Usage: | Diabetes mellitus type 1 |
Gene Name: | GAD1 glutamate decarboxylase 1 (brain, 67kDa) [ Homo sapiens (human) ] |
Official Symbol: | GAD1 |
Synonyms: | GAD1; glutamate decarboxylase 1 (brain, 67kDa); GAD, glutamate decarboxylase 1 (brain, 67kD); glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform; GAD; SCP; CPSQ1; FLJ45882; |
GeneID: | 2571 |
mRNA Refseq: | NM_000817 |
Protein Refseq: | NP_000808 |
MIM: | 605363 |
UniProt ID: | Q99259 |
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Not For Human Consumption!
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