Recombinant Human IL2 Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
IL2-084THP |
| Common Name: |
IL2 |
| Product Name: |
Recombinant Human IL2 Protein, GMP Grade |
| Product Overview: |
Recombinant human IL2 Protein without tag was expressed in E. coli and was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. |
| Source: |
E. coli |
| Species: |
Human |
| Bio-activity: |
150 μg/mL |
| Molecular Mass: |
57647.3 Da |
| AA Sequence: |
MGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTHAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Purity: |
> 99 % by SDS-PAGE and HPLC analysis |
| Applications: |
For treatment of cutaneous T-cell lymphoma. |
| Usage: |
Cutaneous T-cell lymphoma |
| Gene Name: |
IL2 interleukin 2 [ Homo sapiens (human) ] |
| Official Symbol: |
IL2 |
| Synonyms: |
IL2; interleukin 2; IL-2; TCGF; lymphokine; interleukin-2; T cell growth factor; aldesleukin; involved in regulation of T-cell clonal expansion |
| GeneID: |
3558 |
| mRNA Refseq: |
NM_000586 |
| Protein Refseq: |
NP_000577 |
| MIM: |
147680 |
| UniProt ID: |
P01585 |
Not For Human Consumption!
