Recombinant Human IL4 Protein, GMP Grade
- Specification
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| Cat#: |
IL4-083THP |
| Common Name: |
IL4 |
| Product Name: |
Recombinant Human IL4 Protein, GMP Grade |
| Product Overview: |
Recombinant Human IL4 Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Species: |
Human |
| Form: |
Lyophilized |
| Endotoxin: |
<0.1 EU/μg of the protein by the LAL method |
| Purity: |
≥98 % (SDS-PAGE) |
| Applications: |
Interleukin-4 is used as a biological response modifier to boost the immune system in cancer therapy. |
| Usage: |
Boost the immune system in cancer therapy |
| Storage: |
Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 centigrade for 1 week. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
| Storage Buffer: |
Lyophilized from a 0.2 μm concentrated (1mg/mL) solution in PBS pH 7.4. |
| Gene Name: |
IL4 interleukin 4 [ Homo sapiens (human) ] |
| Official Symbol: |
IL4 |
| Synonyms: |
IL4; interleukin 4; interleukin-4; B cell growth factor 1; B_cell stimulatory factor 1; BCGF 1; BCGF1; BSF1; IL 4; lymphocyte stimulatory factor 1; MGC79402; binetrakin; pitrakinra; IL-4; BSF-1; BCGF-1; |
| GeneID: |
3565 |
| mRNA Refseq: |
NM_000589 |
| Protein Refseq: |
NP_000580 |
| MIM: |
147780 |
| UniProt ID: |
P05112 |
Not For Human Consumption!
