Recombinant Human SMPD1 Protein, GMP Grade
- Specification
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| Cat#: |
SMPD1-072THP |
| Common Name: |
SMPD1 |
| Product Name: |
Recombinant Human SMPD1 Protein, GMP Grade |
| Product Overview: |
Recombinant Human SMPD1 Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. |
| Species: |
Human |
| Molecular Mass: |
63590.93 Da |
| AA Sequence: |
HPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC |
| Endotoxin: |
<0.1 EU/μg of the protein by the LAL method |
| Purity: |
> 95 % by SDS-PAGE and HPLC analysis |
| Usage: |
Human Acid Sphingomyelinase Deficiency; Sphingomyelin Lipidosis |
| Gene Name: |
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal [ Homo sapiens (human) ] |
| Official Symbol: |
SMPD1 |
| Synonyms: |
SMPD1; sphingomyelin phosphodiesterase 1, acid lysosomal; sphingomyelin phosphodiesterase; acid sphingomyelinase; ASM; NPD; ASMASE; |
| GeneID: |
6609 |
| mRNA Refseq: |
NM_000543 |
| Protein Refseq: |
NP_000534 |
| MIM: |
607608 |
| UniProt ID: |
P17405 |
Not For Human Consumption!
