Recombinant Human TNFSF10 Protein, GMP Grade
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| Cat#: |
TNFSF10-069THP |
| Common Name: |
TNFSF10 |
| Product Name: |
Recombinant Human TNFSF10 Protein, GMP Grade |
| Product Overview: |
Recombinant Human TRAIL Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Species: |
Human |
| Molecular Mass: |
19.492 kDa |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Purity: |
> 99 % by SDS-PAGE and HPLC analysis |
| Applications: |
Treatment of metastatic non-small cell lung cancer. |
| Usage: |
Colorectal Cancers; Metastatic Colorectal Cancer (MCRC); Lung Cancer Non-Small Cell Cancer (NSCLC) |
| Gene Name: |
TNFSF10 TNF superfamily member 10 [ Homo sapiens (human) ] |
| Official Symbol: |
TNFSF10 |
| Synonyms: |
TNFSF10; TNF superfamily member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand 6A; tumor necrosis factor superfamily member 10 |
| GeneID: |
8743 |
| mRNA Refseq: |
NM_003810 |
| Protein Refseq: |
NP_003801 |
| MIM: |
603598 |
| UniProt ID: |
P50591 |
Not For Human Consumption!
