Recombinant Porcine F8 Protein, GMP Grade
- Specification
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| Cat#: |
F8-097THP |
| Common Name: |
F8 |
| Product Name: |
Recombinant Porcine F8 Protein, GMP Grade |
| Product Overview: |
Recombinant Porcine F8 Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. |
| Species: |
Porcine |
| Bio-activity: |
500 U/ml |
| Molecular Mass: |
170000.0 Da (Approximate, B-Domain deleted) |
| AA Sequence: |
Not Available |
| Endotoxin: |
<0.001 EU/μg by the LAL method |
| Purity: |
> 99 % by SDS-PAGE and HPLC analysis |
| Applications: |
Indicated for the treatment of bleeding episodes in adults with acquired hemophilia A. |
| Usage: |
Acquired hemophilia A |
| Gene Name: |
F8 coagulation factor VIII [ Sus scrofa (pig) ] |
| Official Symbol: |
F8 |
| Synonyms: |
F8; coagulation factor VIII; coagulation factor VIII; coagulation factor VIII, procoagulant component (hemophilia A); factor VIII; procoagulant component |
| GeneID: |
397339 |
| mRNA Refseq: |
NM_214167 |
| Protein Refseq: |
NP_999332 |
| UniProt ID: |
A0A480HQK2 |
Not For Human Consumption!
