Synthetic Human GALNS Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
GALNS-088THP |
| Common Name: |
GALNS |
| Product Name: |
Synthetic Human GALNS Protein, GMP Grade |
| Product Overview: |
Synthetic Human GALNS Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. |
| Species: |
Human |
| Bio-activity: |
1 mg/mL |
| Molecular Mass: |
110800.0 Da |
| AA Sequence: |
APQPPNILLLLMDDMGWGDLGVYGEPSRETPLCSPSRAALLTGRLPIRNGFYTTNAHARNLLKKAGYVSKIVGKWHLGHRPQFHPLKHGFNIPVYRDWEMVGRYYEEFPINLKTGEANLTFLYWAVDATHAPVYASKPFLGTSQRGRYGDVADNTFVFFTSDNGAALISAPEQGGSNGPFPGHVTAGQVSHQLGSIMDLFTTSLALAGLTLMDRPIFYYRGDTLMAATLGQHKAHFWTWTVTTHNLEDHTKLPLIFHLGRDPGERFPLSFEALVPAQPQLNVCNWAVMNWAPPGCEKLGKPNLDRMAAEGLLFPNFYSANAYTPQEIVGGIPDSEQLLPEDEWFGSPNCHFGPYDNKARPQIYLQEALDFIKRQARHHPFAVREIDDSIGKILELLQDLHLCGKQTTFEGGMREPALAWWPPSDRAIDGLNLLPTLLQGRNSWENFRQGIDFCPGQNVSGASAEYQEALSRITSVVQQHQCLTPPESIPKKCLWSH |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Purity: |
> 99 % by SDS-PAGE and HPLC analysis |
| Applications: |
The product is a hydrolytic lysosomal glycosaminoglycan (GAG)-specific enzyme indicated for patients with Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome). |
| Usage: |
Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) |
| Gene Name: |
GALNS galactosamine (N-acetyl)-6-sulfate sulfatase [ Homo sapiens (human) ] |
| Official Symbol: |
GALNS |
| Synonyms: |
GALNS; galactosamine (N-acetyl)-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfatase; GALNAC6S; GAS; Morquio syndrome; mucopolysaccharidosis type IVA; chondroitinase; galNAc6S sulfatase; chondroitinsulfatase; galactose-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; MPS4A; FLJ17434; FLJ42844; FLJ98217; |
| GeneID: |
2588 |
| mRNA Refseq: |
NM_000512 |
| Protein Refseq: |
NP_000503 |
| MIM: |
612222 |
| UniProt ID: |
P34059 |
Not For Human Consumption!
