Synthetic Human PTHLH Protein, GMP Grade
- Specification
- Related Products
| Cat#: |
PTHLH-075THP |
| Common Name: |
PTHLH |
| Product Name: |
Synthetic Human PTHLH Protein, GMP Grade |
| Product Overview: |
Synthetic Human PTHLH Protein without tag was produced in an animal component free process under cGMP guidelines. |
| Description: |
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. |
| Source: |
synthetic peptide |
| Species: |
Human |
| Bio-activity: |
2000 μg/mL |
| Molecular Mass: |
3961.0 Da |
| AA Sequence: |
AVSEHQLLHDKGKSIQDLRRRELLEKLLXKLHTA |
| Endotoxin: |
<0.001 EU/μg of the peptide by the LAL method |
| Purity: |
> 99.5 % by SDS-PAGE and HPLC analysis |
| Applications: |
Investigated for use/treatment in postmenopausal osteoporosis to reduce vertebral and/or non-vertebral fractures. |
| Usage: |
Postmenopausal osteoporosis |
| Storage: |
Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 centigrade for 1 week. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
| Gene Name: |
PTHLH parathyroid hormone-like hormone [ Homo sapiens (human) ] |
| Official Symbol: |
PTHLH |
| Synonyms: |
PTHLH; parathyroid hormone-like hormone; parathyroid hormone-related protein; HHM; osteostatin; PLP; PTHR; PTHRP; PTH-rP; PTH-related protein; parathyroid hormone-like related protein; BDE2; MGC14611; |
| GeneID: |
5744 |
| mRNA Refseq: |
NM_002820 |
| Protein Refseq: |
NP_002811 |
| UniProt ID: |
P12272 |
Not For Human Consumption!
