Cytokines are small water-soluble signaling proteins and glycoproteins secreted by hematopoietic and non-hematopoietic cells of the immune system. Some cytokines are primarily lymphocyte growth factors, some function as pro- or anti-inflammatory, while others polarize the immune response to antigens. Their signaling action can be within the same cell (autocrine), on neighbouring cells (paracrine), or on distant cells through the bloodstream (endocrine). These signaling molecules play important roles in a variety of biological processes, including cell proliferation, differentiation, migration, metabolism, wound healing, inflammation, etc.

The critical role of cytokines in life processes makes them essential for culturing living cells in laboratory environment, where they can be used to induce stem cell differentiation or as growth supplements in culture medium. As more biotherapeutics are developed, special attention needs to be paid to the quality of the raw materials used, such as cytokines and growth factors, from preclinical research and development to clinical trials. At present, cytokines have become the frontier of medical research and play an indispensable role in the diagnosis, prognosis and drug development of diseases, especially in the fields of inflammation, immunology, atherosclerosis and cancer research.

GMP grade cytokines in Creative BioMart

Quality management system has always been the focus of the industry. In the process of immunotherapy research, these cytokine products must be safe and effective. As a leading recombinant protein supplier, Creative BioMart is based on the GMP-grade quality management system platform, combined with the production specifications of cell therapy drugs, to provide consistent, safe and traceable GMP protein reagents for therapeutic manufacturers. At present, we have developed a series of high-quality GMP-grade cytokines to better facilitate the research of immune cell therapy drugs and accelerate the global regulatory approval of biological products.

We have an advanced and scale-up ready protein development platform with over 10 years of experience in GMP protein production. We strictly adhere to GMP guidelines with our comprehensive quality management system and quality controls to provide you with high-quality raw materials and accelerate your development process. Customized one-stop services to maximize your project success.

Quality Standards

• High biological activity
• Multiple expression systems
• High purity, SDS-PAGE>95%
• Low endotoxin levels
• Batch-to-batch consistency
• Microbial and mycoplasma testing
• In vitro virus assay

Quality Management System

• ISO 5 cleanrooms
• Automatic filling equipment
• Batch production and control records
• Stability study
• Manufacturing and QC testing according to GMP compliance
• Comprehensive regulatory support files

As an industry leader in GMP-grade protein manufacturing, Creative BioMart can provide small-scale and large-scale GMP production, formulation, and filling/finishing. Our products are generated from the same cloning and expression system as research-grade proteins, and allow various manufacturing scales from 10L to 500L to meet all customer needs from academic research to commercial production. Welcome to contact us for more detailed information.

Product List

* For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

References
1. Dinarello, C.A. Historical Review of Cytokines. Eur J Immunol. 2011.
2. O’Shea, J.J; et al. Cytokines and autoimmunity. Nat Rev Immunol. 2002.